Whether it is possible to delay initiation of blood pressure management until later in pregnancy to offset the effect of antihypertensive treatment- CHIPS TRIAL
Whether it is possible to delay initiation of blood pressure management until later in pregnancy to offset the effect of antihypertensive treatment on birth weight was explored in a post-hoc analysis of data from the CHIPS trial Less tight (diastolic target 100 mmHg) versus tight (diastolic target 85 mmHg) control at <24 weeks was associated with fewer newborn weights <10th percentile, but an increase in iatrogenic preterm birth and development of severe maternal hypertension, with no overall effect on perinatal death or morbidity. In pregnant women with chronic hypertension, our treatment target throughout pregnancy is systolic pressure 130 to 150 mmHg and diastolic pressure 80 to 100 mmHg.
Reference:
PubMed TIInfluence of Gestational Age at Initiation of Antihypertensive Therapy: Secondary Analysis of CHIPS Trial Data (Control of Hypertension in Pregnancy Study).AUPels A, Mol BWJ, Singer J, Lee T, von Dadelszen P, Ganzevoort W, Asztalos E, Magee LA, CHIPS Study Group SOHypertension. 2018;71(6):1170. Epub 2018 Apr 23.